MNT and MutaMouse studies to define the in vivo dose response relations of the genotoxicity of EMS and ENU.

Abstract excerpt

Although there are a multitude of in vitro and in vivo studies on the genotoxic activity of EMS, no lifetime carcinogenicity studies, repeat dose mutation data or exposure analysis are available to serve as a solid basis for risk assessment for human exposure cases. The present studies were under...

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