Article

The trypanosome Variant Surface Glycoprotein mRNA is stabilized by an essential unconventional RNA-binding protein

2020-10-08

Abstract excerpt

Salivarian trypanosomes cause human sleeping sickness and economically important livestock diseases. The “bloodstream forms”, which replicate extracellularly in the blood and tissue fluids of mammals, are coated by a monolayer of Variant Surface Glycoprotein (VSG). Switching of the expressed VSG gene is central to parasite pathogenicity because it enables the parasites to evade adaptive immunity via antigenic var...

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Literature Corpus work: 48ca0827-6d95-5d4a-bd43-1d0ea2ba7aee
DOI: 10.1101/2020.10.08.331769

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