Article

Mechanisms of evasion of the African trypanosome : Trypanosoma brucei from the host innate and adaptive immune system

2017-01-01

Abstract excerpt

The extracellular bloodstream form Trypanosoma brucei is the causative agent of Human African Trypanosomiasis (HAT). It is highly adapted to escape both the innate and adaptive immune systems of the mammalian host, which is mediated through a dense Variant Surface Glycoprotein (VSG) coat. Two main mechanisms of evasion are known to provide protection for the parasite in the bloodstream: antigenic variation and hig...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e3999f5a-313f-5ff7-bbe7-9e8fba124dec
DOI: 10.25560/83766

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mechanisms of evasion of the African trypanosome : Trypanosoma brucei from the host innate and adaptive immune systemDOI 10.25560/83766Read

African trypanosomes: the genome and adaptations for immune evasionSemantic proximity Read

A Host-Pathogen Interaction Reduced to First Principles: Antigenic Variation in T. brucei.Semantic proximity Read

Comparative Analysis of Virulence Mechanisms of Trypanosomatids Pathogenic to HumansSemantic proximity Read

Escape mechanisms of African trypanosomes: why trypanosomosis is keeping us awakeSemantic proximity Read

Bloodstream form trypanosome plasma membrane proteins: antigenic variation and invariant antigensSemantic proximity Read

To the Surface and Back: Exo- and Endocytic Pathways in Trypanosoma bruceiSemantic proximity Read

Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomesSemantic proximity Read

Escaping Deleterious Immune Response in Their Hosts: Lessons from TrypanosomatidsSemantic proximity Read

An Overview of Trypanosoma brucei Infections: An Intense Host–Parasite InteractionSemantic proximity Read

Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to PathogenicitySemantic proximity Read

Faster growth with shorter antigens explains a VSG hierarchy during African trypanosome infections: a feint attack by parasitesSemantic proximity Read

VSG-GPI anchors of African trypanosomes: their role in macrophage activation and induction of infection-associated immunopathologySemantic proximity Read