Article
Tregs control the development of symptomatic West Nile virus infection in humans and mice.
The Journal of clinical investigation - 1 Nov 2009
Lanteri Marion C, O'Brien Katie M, Purtha Whitney E, Cameron Mark J, Lund Jennifer M, Owen Rachel E, Heitman John W, Custer Brian, Hirschkorn Dale F, Tobler Leslie H, Kiely Nancy, Prince Harry E, Ndhlovu Lishomwa C, Nixon Douglas F, Kamel Hany T, Kelvin David J, Busch Michael P, Rudensky Alexander Y, Diamond Michael S, Norris Philip J
Abstract excerpt
West Nile virus (WNV) causes asymptomatic infection in most humans, but for undefined reasons, approximately 20% of immunocompetent individuals develop West Nile fever, a potentially debilitating febrile illness, and approximately 1% develop neuroinvasive disease syndromes. Notably, since its emergence in 1999, WNV has become the leading cause of epidemic viral encephalitis in North America. We hypothesized that...
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