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Article

LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis.

Developmental cell - 1 Oct 2009

Maeda Takahiro, Ito Keisuke, Merghoub Taha, Poliseno Laura, Hobbs Robin M, Wang Guocan, Dong Lin, Maeda Manami, Dore Louis C, Zelent Arthur, Luzzatto Lucio, Teruya-Feldstein Julie, Weiss Mitchell J, Pandolfi Pier Paolo

Abstract excerpt

GATA-1-dependent transcription is essential for erythroid differentiation and maturation. Suppression of programmed cell death is also thought to be critical for this process; however, the link between these two features of erythropoiesis has remained elusive. Here, we show that the POZ-Krüppel f...

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Identifiers

PMID: 19853566
DOI: 10.1016/j.devcel.2009.09.005
PMCID: PMC3134301

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19853566-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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