Article
Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1.
Nature - 30 Sept 1999
De Maria R, Zeuner A, Eramo A, Domenichelli C, Bonci D, Grignani F, Srinivasula S M, Alnemri E S, Testa U, Peschle C
Abstract excerpt
The production of red blood cells follows the sequential formation of proerythroblasts and basophilic, polychromatophilic and orthochromatic erythroblasts, and is promoted by the hormone erythropoietin (Epo) in response to tissue hypoxia. However, little is known about the negative regulation of this process. Death receptors are a family of surface molecules that trigger caspase activation and apoptosis in a...
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