Article
Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes
25 Jul 2022
Abstract excerpt
The kidneys generate about 180 l of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component. Filter dysfunction typically manifests with proteinuria and mutations in endocytosis regulating genes were discovered as causes of proteinuria. However, it is unclear how endocytosis regulates the slit...
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