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A flexible, multilayered protein scaffold maintains the slit in between glomerular podocytes

15 Jun 2016

Abstract excerpt

Vertebrate life critically depends on renal filtration and excretion of low molecular weight waste products. This process is controlled by a specialized cell-cell contact between podocyte foot processes: the slit diaphragm (SD). Using a comprehensive set of targeted KO mice of key SD molecules, we provided genetic, functional, and high-resolution ultrastructural data highlighting a concept of a flexible, dynamic,...

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Share to Chronic Kidney Disease and Diabetes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27430022
DOI: 10.1172/jci.insight.86177

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