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AA genotype of IL-8 -251A/T is associated with low PaO(2)/FiO(2) in critically ill patients and with increased IL-8 expression.

Respirology (Carlton, Vic.) - 1 Nov 2012

Wacharasint Petch, Nakada Taka-aki, Boyd John H, Russell James A, Walley Keith R

Abstract excerpt

BACKGROUND AND OBJECTIVE: Interleukin-8 (IL-8) is a central chemokine in acute respiratory distress syndrome (ARDS), and the IL-8 gene contains a functional single nucleotide polymorphism (SNP) -251A/T in its promoter region. We hypothesized that IL-8 -251A/T SNP is associated with PaO(2)/FiO(2) in critically ill patients. METHODS: We conducted genetic-association studies in intensive care units at academic...

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PMID: 22897124
DOI: 10.1111/j.1440-1843.2012.02244.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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