Article
Genetic and expression analysis of all 7 non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease II gene, with potential relevance to autoimmunity.
Clinica chimica acta; international journal of clinical chemistry - 1 Jan 2010
Ueki Misuzu, Takeshita Haruo, Fujihara Junko, Kimura-Kataoka Kaori, Iida Reiko, Yuasa Isao, Nakajima Tamiko, Kominato Yoshihiko, Yasuda Toshihiro
Abstract excerpt
BACKGROUND: Several non-synonymous SNPs in the human DNase II gene, potentially relevant to autoimmunity, have been identified, but only limited population data are available. Also, the effects of these SNPs on the catalytic activity of the enzyme remain unknown. METHODS: Genotyping of all the non-synonymous SNPs was performed in healthy subjects of 3 ethnic groups including 6 different populations using the...
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