Article
A biochemical and genetic study on all non-synonymous single nucleotide polymorphisms of the gene encoding human deoxyribonuclease I potentially relevant to autoimmunity.
The international journal of biochemistry & cell biology - 1 Jul 2010
Yasuda Toshihiro, Ueki Misuzu, Takeshita Haruo, Fujihara Junko, Kimura-Kataoka Kaori, Iida Reiko, Tsubota Etsuko, Soejima Mikiko, Koda Yoshiro, Kato Hideaki, Panduro Arturo
Abstract excerpt
A reduction of deoxyribonuclease I (DNase I) activity levels in the serum of patients with autoimmune diseases has been reported. The objectives of this study were to clarify genetic and biochemical aspects of 12 non-synonymous SNPs in the human gene (DNASE1), potentially giving rise to an alteration in the in vivo DNase I activity levels. Genotyping of all the non-synonymous SNPs was performed in healthy...
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