Article
Evaluation of all non-synonymous single nucleotide polymorphisms (SNPs) in the genes encoding human deoxyribonuclease I and I-like 3 as a functional SNP potentially implicated in autoimmunity.
The FEBS journal - 1 Jan 2014
Ueki Misuzu, Kimura-Kataoka Kaori, Takeshita Haruo, Fujihara Junko, Iida Reiko, Sano Rie, Nakajima Tamiko, Kominato Yoshihiko, Kawai Yasuyuki, Yasuda Toshihiro
Abstract excerpt
The objectives of this study were to evaluate all the non-synonymous single nucleotide polymorphisms (SNPs) in the DNase I and DNase I-like 3 (1L3) genes potentially implicated in autoimmune diseases as a functional SNP in terms of alteration of the activity levels. We examined the genotype distributions of the 32 and 20 non-synonymous SNPs in DNASE1 and DNASE1L3, respectively, in three ethnic groups, and the...
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