Article
Caucasian-specific allele in non-synonymous single nucleotide polymorphisms of the gene encoding deoxyribonuclease I-like 3, potentially relevant to autoimmunity, produces an inactive enzyme.
Clinica chimica acta; international journal of clinical chemistry - 1 Sept 2009
Ueki Misuzu, Takeshita Haruo, Fujihara Junko, Iida Reiko, Yuasa Isao, Kato Hideaki, Panduro Arturo, Nakajima Tamiko, Kominato Yoshihiko, Yasuda Toshihiro
Abstract excerpt
BACKGROUND: Deoxyribonuclease I-like 3 (DNase Il3), a member of human DNase I family, is postulated to be involved in the genesis of autoimmune diseases. In the DNase Il3 gene, 2 non-synonymous SNPs, R178H and R206C, have been identified, however relevant population data are not available. METHODS: Genotyping of the SNPs was performed in healthy subjects belonging to 3 ethnic groups (n=1708), including nine...
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