Article
Functional and genetic survey of all known single-nucleotide polymorphisms within the human deoxyribonuclease I gene in wide-ranging ethnic groups.
DNA and cell biology - 1 Apr 2011
Fujihara Junko, Ueki Misuzu, Yasuda Toshihiro, Iida Reiko, Soejima Mikiko, Koda Yoshiro, Kimura-Kataoka Kaori, Kato Hideaki, Panduro Arturo, Tongu Miki, Takeshita Haruo
Abstract excerpt
The single-nucleotide polymorphisms (SNPs) in the human DNase I gene (DNASE1) might be involved in susceptibility to some common diseases; however, only limited population data are available. Further, the effects of these SNPs on in vivo DNase I activity remain unknown. The genotype and haplotype of all the SNPs in DNASE1 were determined in 3 ethnic groups including 14 populations using newly developed methods....
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