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Article

Functional Single Nucleotide Polymorphisms (SNPs) in the Genes Encoding the Human Deoxyribonuclease (DNase) Family Potentially Relevant to Autoimmunity.

Immunological investigations - 1 Jul 2016

Fujihara Junko, Ueki Misuzu, Kimura-Kataoka Kaori, Iida Reiko, Takeshita Haruo, Yasuda Toshihiro

Abstract excerpt

OBJECTIVE: To continue our previous investigations, we have extensively investigated the function of the 61, 41, and 35 non-synonymous single nucleotide polymorphisms (SNPs) in the human genes encoding DNASE1, DNASE1L3, and DNASE2, respectively, potentially relevant to autoimmune diseases. METHODS: The site-directed mutagenesis was employed to amino acid-substituted constructs corresponding to each SNP. The COS-7...

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Identifiers

PMID: 27116004
DOI: 10.3109/08820139.2016.1157813

Genes

DNASE1
DNASE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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