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Article

Structural Insights into the MMACHC-MMADHC Protein Complex Involved in Vitamin B12 Trafficking.

The Journal of biological chemistry - 4 Dec 2015

Froese D Sean, Kopec Jolanta, Fitzpatrick Fiona, Schuller Marion, McCorvie Thomas J, Chalk Rod, Plessl Tanja, Fettelschoss Victoria, Fowler Brian, Baumgartner Matthias R, Yue Wyatt W

Abstract excerpt

Conversion of vitamin B12 (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCbl) and adenosyl-Cbl (AdoCbl) is required for the function of two crucial enzymes, mitochondrial methylmalonyl-CoA mutase and cytosolic methionine synthase, respectively. The intracellular proteins MMACHC and MMADHC play important roles in processing and targeting the Cbl cofactor to its destination enzymes, and recent evidence...

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Source

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Identifiers

PMID: 26483544
DOI: 10.1074/jbc.M115.683268
PMCID: PMC4705923

Genes

MMACHC
MMADHC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural Insights into the MMACHC-MMADHC Protein Complex Involved in Vitamin B12 Trafficking.PMID 26483544Read ↗

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Structures of the Human GTPase MMAA and Vitamin B12-dependent Methylmalonyl-CoA Mutase and Insight into Their Complex FormationSemantic proximity Read ↗

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