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Article

A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins.

The Journal of biological chemistry - 27 Nov 2009

Kim Jihoe, Hannibal Luciana, Gherasim Carmen, Jacobsen Donald W, Banerjee Ruma

Abstract excerpt

Pathways for tailoring and processing vitamins into active cofactor forms exist in mammals that are unable to synthesize these cofactors de novo. A prerequisite for intracellular tailoring of alkylcobalamins entering from the circulation is removal of the alkyl group to generate an intermediate that can subsequently be converted into the active cofactor forms. MMACHC, a cytosolic cobalamin trafficking chaperone,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19801555
DOI: 10.1074/jbc.M109.057877
PMCID: PMC2785186

Genes

MMACHC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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