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Article

Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.

Biochemistry - 26 Jun 2012

Froese D Sean, Krojer Tobias, Wu Xuchu, Shrestha Roshi, Kiyani Wasim, von Delft Frank, Gravel Roy A, Oppermann Udo, Yue Wyatt W

Abstract excerpt

Defects in the MMACHC gene represent the most common disorder of cobalamin (Cbl) metabolism, affecting synthesis of the enzyme cofactors adenosyl-Cbl and methyl-Cbl. The encoded MMACHC protein binds intracellular Cbl derivatives with different upper axial ligands and exhibits flavin mononucleotide (FMN)-dependent decyanase activity toward cyano-Cbl as well as glutathione (GSH)-dependent dealkylase activity toward...

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Source

Identifiers

PMID: 22642810
DOI: 10.1021/bi300150y

Genes

MMACHC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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