Article
Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish.
Blood - 10 Dec 2009
Belele Christiane L, English Milton A, Chahal Jagman, Burnetti Anthony, Finckbeiner Steven M, Gibney Gretchen, Kirby Martha, Sood Raman, Liu P Paul
Abstract excerpt
The transcription factor Gata1 is required for the development of erythrocytes and megakaryocytes. Previous studies with a complementation rescue approach showed that the zinc finger domains are required for both primitive and definitive hematopoiesis. Here we report a novel zebrafish gata1 mutant with an N-ethyl-N-nitrosourea-induced point mutation in the C-finger (gata1(T301K)). The Gata1 protein with this...
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