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Inhibition of red blood cell development by arsenic-induced disruption of GATA-1

4 Nov 2020

Abstract excerpt

Anemia is a hematological disorder that adversely affects the health of millions of people worldwide. Although many variables influence the development and exacerbation of anemia, one major contributing factor is the impairment of erythropoiesis. Normal erythropoiesis is highly regulated by the zinc finger transcription factor GATA-1. Disruption of the zinc finger motifs in GATA-1, such as produced by germline...

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Share to Erythrocyte Function and Pathophysiology
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PMID: 33149232
DOI: 10.1038/s41598-020-76118-x

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