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Article

Fibroblast-secreted hepatocyte growth factor plays a functional role in esophageal squamous cell carcinoma invasion.

Proceedings of the National Academy of Sciences of the United States of America - 15 Jun 2010

Grugan Katharine D, Miller Charles G, Yao Yao, Michaylira Carmen Z, Ohashi Shinya, Klein-Szanto Andres J, Diehl J Alan, Herlyn Meenhard, Han May, Nakagawa Hiroshi, Rustgi Anil K

Abstract excerpt

Squamous cell cancers comprise the most common type of human epithelial cancers. One subtype, esophageal squamous cell carcinoma (ESCC), is an aggressive cancer with poor prognosis due to late diagnosis and metastasis. Factors derived from the extracellular matrix (ECM) create an environment conducive to tumor growth and invasion. Specialized cancer-associated fibroblasts (CAFs) in the ECM influence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-met

Source

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Identifiers

PMID: 20534479
DOI: 10.1073/pnas.0914295107
PMCID: PMC2890722

Genes

HGF
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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