Article
High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts.
PloS one - 1 Jan 2015
Rudisch Albin, Dewhurst Matthew Richard, Horga Luminita Gabriela, Kramer Nina, Harrer Nathalie, Dong Meng, van der Kuip Heiko, Wernitznig Andreas, Bernthaler Andreas, Dolznig Helmut, Sommergruber Wolfgang
Abstract excerpt
We established co-cultures of invasive or non-invasive NSCLC cell lines and various types of fibroblasts (FBs) to more precisely characterize the molecular mechanism of tumor-stroma crosstalk in lung cancer. The HGF-MET-ERK1/2-CREB-axis was shown to contribute to the onset of the invasive phenotype of Calu-1 with HGF being secreted by FBs. Differential expression analysis of the respective mono- and co-cultures...
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