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Article

Fibroblasts Influence Survival and Therapeutic Response in a 3D Co-Culture Model

8 Jun 2015

Abstract excerpt

In recent years, evidence has indicated that the tumor microenvironment (TME) plays a significant role in tumor progression. Fibroblasts represent an abundant cell population in the TME and produce several growth factors and cytokines. Fibroblasts generate a suitable niche for tumor cell survival and metastasis under the influence of interactions between fibroblasts and tumor cells. Investigating these...

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PMID: 26053043
DOI: 10.1371/journal.pone.0127948

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