Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice.

doi:10.1111/j.1755-148X.2009.00646.x

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Article

Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice.

Pigment cell & melanoma research - 1 Feb 2010

Murillo-Cuesta Silvia, Contreras Julio, Zurita Esther, Cediel Rafael, Cantero Marta, Varela-Nieto Isabel, Montoliu Lluís

Abstract excerpt

Strial melanocytes are required for normal development and correct functioning of the cochlea. Hearing deficits have been reported in albino individuals from different species, although melanin appears to be not essential for normal auditory function. We have analyzed the auditory brainstem responses (ABR) of two transgenic mice: YRT2, carrying the entire mouse tyrosinase (Tyr) gene expression-domain and...

Topics

Aging
Aging, Premature
Albinism
Albinism, Oculocutaneous
Animals
Disease Models, Animal
Evoked Potentials, Auditory, Brain Stem
Gene Expression Regulation, Enzymologic
Genetic Predisposition to Disease
Hearing Loss, Noise-Induced
Hearing Loss, Sensorineural
Levodopa

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Melanins

Mice

Mice, Transgenic

Monophenol Monooxygenase

Tyrosine 3-Monooxygenase

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Open in PubMed

Identifiers

PMID: 19843244
DOI: 10.1111/j.1755-148X.2009.00646.x

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