The mouse brown (b/Tyrp1(b) ) allele does not affect pheomelanin synthesis in mice.

Abstract excerpt

B (Tyrp1 (+)), the wild type allele at the mouse brown locus, produces black eumelanin, while b (Tyrp1(b) ), the recessive allele, produces brown eumelanin and exhibits lower tyrosinase (Tyr)-related protein 1 (Tyrp1) activity. However, it is unknown whether melanocyte proliferation and differentiation are affected by the Tyrp1(b) mutation. The proliferation rate of brown (C57BL/10JHir (B10)-Tyrp1(b) / Tyrp1(b) )...

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