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Article

A dominant mutation in tyrp1A leads to melanophore death in zebrafish.

Pigment cell & melanoma research - 1 Sept 2014

Krauss Jana, Geiger-Rudolph Silke, Koch Iris, Nüsslein-Volhard Christiane, Irion Uwe

Abstract excerpt

Melanin biosynthesis in vertebrates depends on the function of three enzymes of the tyrosinase family, tyrosinase (Tyr), tyrosinase-related protein 1 (Tyrp1), and dopachrome tautomerase (Dct or Tyrp2). Tyrp1 might play an additional role in the survival and proliferation of melanocytes. Here, we describe a mutation in tyrp1A, one of the two tyrp1 paralogs in zebrafish, which causes melanophore death leading to a...

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PMID: 24891189
DOI: 10.1111/pcmr.12272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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