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Article

Experimental determination of the evolvability of a transcription factor.

Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2009

Maerkl Sebastian J, Quake Stephen R

Abstract excerpt

Sequence-specific binding of a transcription factor to DNA is the central event in any transcriptional regulatory network. However, relatively little is known about the evolutionary plasticity of transcription factors. For example, the exact functional consequence of an amino acid substitution on the DNA-binding specificity of most transcription factors is currently not predictable. Furthermore, although the...

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Identifiers

PMID: 19841254
DOI: 10.1073/pnas.0907688106
PMCID: PMC2765923

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