Article
DNAdesign: feature-aware in silico design of synthetic DNA through mutation.
Bioinformatics (Oxford, England) - 4 Feb 2025
Wang Yingfei, Li Jinsen, Chiu Tsu-Pei, Gompel Nicolas, Rohs Remo
Abstract excerpt
MOTIVATION: DNA sequence and shape readout represent different modes of protein-DNA recognition. Current tools lack the functionality to simultaneously consider alterations in different readout modes caused by sequence mutations. DNAdesign is a web-based tool to compare and design mutations based on both DNA sequence and shape characteristics. Users input a wild-type sequence, select sites to introduce mutations...
Read the complete abstract on PubMedTopics
- DNA
- Software
- Mutation
- Nucleic Acid Conformation
- Computer Simulation
- Computational Biology
- Binding Sites