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Article

Snf1p regulates Gcn5p transcriptional activity by antagonizing Spt3p.

Genetics - 1 Jan 2010

Liu Yang, Xu Xinjing, Kuo Min-Hao

Abstract excerpt

The budding yeast Gcn5p is a prototypic histone acetyltransferase controlling transcription of diverse genes. Here we show that Gcn5p is itself regulated by Snf1p and Spt3p. Snf1p likely controls Gcn5p via direct interaction. Mutating four residues in the Gcn5p catalytic domain, T203, S204, T211, and Y212 (TSTY), phenocopies snf1 null cells, including Gcn5p hypophosphorylation, hypoacetylation at the HIS3...

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Identifiers

PMID: 19841091
DOI: 10.1534/genetics.109.110957
PMCID: PMC2815934

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Source receipt: pubmed, retrieved 7 Sept 2026.

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