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Article

Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis.

Infection and immunity - 1 Jan 2010

Whitfield Natalie N, Byrne Brenda G, Swanson Michele S

Abstract excerpt

Legionella pneumophila, a motile opportunistic pathogen of humans, is restricted from replicating in the lungs of C57BL/6 mice. Resistance of mouse macrophages to L. pneumophila depends on recognition of cytosolic flagellin. Once detected by the NOD-like receptors Naip5 and Ipaf (Nlrc4), flagellin triggers pyroptosis, a proinflammatory cell death. In contrast, motile strains of L. parisiensis and L. tucsonensis...

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Identifiers

PMID: 19841075
DOI: 10.1128/IAI.00070-09
PMCID: PMC2798216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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