Article
Global cellular changes induced by Legionella pneumophila infection of bone marrow-derived macrophages.
Immunobiology - 1 Dec 2011
Fortier Anne, Faucher Sebastien P, Diallo Kanny, Gros Philippe
Abstract excerpt
The nucleotide-binding oligomerization domain (Nod)-like receptor (NLR) family member Naip5 plays an essential role in restricting Legionella pneumophila growth inside primary macrophages. Upon interaction with bacterial flagellin, the intracellular receptor Naip5 forms a multi-protein complex, the inflammasome, which activation has a protective role against infection. The A/J mouse strain carries a Naip5 allele...
Topics
- Animals
- Apoptosis
- Bacterial Proteins
- Cells, Cultured
- Flagellin
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Immunity, Innate
- Inflammasomes
- Interleukin-1beta
- Legionella pneumophila
- Legionnaires' Disease
- Macrophages
- Mice