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Mouse infection by Legionella, a Model to Analyze Autophagy

22 Jul 2006

Abstract excerpt

Autophagy is a conserved membrane traffic pathway that equips eukaryotic cells to capture cytoplasmic components within a double-membrane vacuole, or autophagosome, for delivery to lysosomes. Although best known as a mechanism to survive starvation, autophagy is now recognized to combat infection by a variety of microbes.(1-3) Not surprisingly, to establish a replication niche in host cells, some intracellular...

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PMID: 16874080
DOI: 10.4161/auto.2831

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