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Article

Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo.

Molecular and cellular biology - 1 Jan 2010

Hübner Anette, Cavanagh-Kyros Julie, Rincon Mercedes, Flavell Richard A, Davis Roger J

Abstract excerpt

Bcl2-modifying factor (Bmf) is a member of the BH3-only group of proapoptotic proteins. To test the role of Bmf in vivo, we constructed mice with a series of mutated Bmf alleles that disrupt Bmf expression, prevent Bmf phosphorylation by the c-Jun NH(2)-terminal kinase (JNK) on Ser(74), or mimic Bmf phosphorylation on Ser(74). We report that the loss of Bmf causes defects in uterovaginal development, including an...

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Identifiers

PMID: 19841067
DOI: 10.1128/MCB.01155-09
PMCID: PMC2798311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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