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Article

Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice.

The American journal of pathology - 1 Nov 2008

Semenova Ekaterina, Koegel Heidi, Hasse Sybille, Klatte Jennifer E, Slonimsky Esfir, Bilbao Daniel, Paus Ralf, Werner Sabine, Rosenthal Nadia

Abstract excerpt

Insulin-like growth factor 1 (IGF-1) is an important regulator of growth, survival, and differentiation in many tissues. It is produced in several isoforms that differ in their N-terminal signal peptide and C-terminal extension peptide. The locally acting isoform of IGF-1 (mIGF-1) was previously shown to enhance the regeneration of both muscle and heart. In this study, we tested the therapeutic potential of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18832567
DOI: 10.2353/ajpath.2008.071177
PMCID: PMC2570121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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