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Article

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins.

The Journal of cell biology - 10 Aug 2009

Mérino Delphine, Giam Maybelline, Hughes Peter D, Siggs Owen M, Heger Klaus, O'Reilly Lorraine A, Adams Jerry M, Strasser Andreas, Lee Erinna F, Fairlie Walter D, Bouillet Philippe

Abstract excerpt

Proteins of the Bcl-2 family are critical regulators of apoptosis, but how its BH3-only members activate the essential effectors Bax and Bak remains controversial. The indirect activation model suggests that they simply must neutralize all of the prosurvival Bcl-2 family members, whereas the direct activation model proposes that Bim and Bid must activate Bax and Bak directly. As numerous in vitro studies have not...

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Identifiers

PMID: 19651893
DOI: 10.1083/jcb.200905153
PMCID: PMC2728397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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