Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A common mutation in paraoxonase-2 results in impaired lactonase activity.

The Journal of biological chemistry - 18 Dec 2009

Stoltz David A, Ozer Egon A, Recker Thomas J, Estin Miriam, Yang Xia, Shih Diana M, Lusis Aldons J, Zabner Joseph

Abstract excerpt

Paraoxonases (PONs) are a family of lactonases with promiscuous enzyme activity that has been implicated in multiple diseases. PON2 is intracellularly located, is the most ubiquitously expressed PON, and has the highest lactonase activity of the PON family members. Whereas some single-nucleotide polymorphisms (SNPs) in PON1 have resulted in altered enzymatic activity in serum, to date the functional consequences...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryldialkylphosphatase
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CHO Cells

Share to Cricetinae

Share to Cricetulus

Share to Glycosylation

Share to Immunity, Innate

Source

Open in PubMed Open full text

Identifiers

PMID: 19840942
DOI: 10.1074/jbc.M109.051706
PMCID: PMC2790986

Genes

PON2
PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common mutation in paraoxonase-2 results in impaired lactonase activity.PMID 19840942Read ↗

A Multi-Omics Analysis of PON1 Lactonase Activity in Relation to Human Health and Disease.Semantic proximity Read ↗

Human paraoxonase-1 (PON1): Gene structure and expression, promiscuous activities and multiple physiological roles.Semantic proximity Read ↗

Paraoxonases: ancient substrate hunters and their evolving role in ischemic heart disease.Semantic proximity Read ↗

Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.Semantic proximity Read ↗

Paraoxonases-1, -2 and -3: What are their functions?Semantic proximity Read ↗

Contribution of the Paraoxonase-2 Enzyme to Cancer Cell Metabolism and Phenotypes.Semantic proximity Read ↗

Paraoxonase genes and disease.Semantic proximity Read ↗

The Ser311Cys variation in the paraoxonase 2 gene increases the risk of type 2 diabetes in northern Chinese.Semantic proximity Read ↗

Paraoxonase 1 activities and genetic variation in childhood obesity.Semantic proximity Read ↗

Molecular Structure of Paraoxonase-1 and Its Modifications in Relation to Enzyme Activity and Biological Functions-A Comprehensive Review.Semantic proximity Read ↗

PON2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients.Semantic proximity Read ↗

A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.