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Article

Molecular Structure of Paraoxonase-1 and Its Modifications in Relation to Enzyme Activity and Biological Functions-A Comprehensive Review.

International journal of molecular sciences - 6 Dec 2024

Lewoń-Mrozek Dominika, Kurzynoga Julia, Jędrzejewski Piotr, Kędzierska Karolina, Partyka Alicja, Kuriata-Kordek Magdalena, Ściskalska Milena

Abstract excerpt

PON1 is a Ca2+-dependent enzyme that indicates a hydrolytic activity towards a broad spectrum of substrates. The mechanism of hydrolysis catalyzed by this enzyme is poorly understood. It was shown that the active site of PON1 is highly dynamic. The catalytic center of this enzyme consists of side chains of amino acids binding two calcium ions, from which the first one performs a structural function and the other...

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Identifiers

PMID: 39684839
DOI: 10.3390/ijms252313129
PMCID: PMC11642642

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