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Article

Contribution of the Paraoxonase-2 Enzyme to Cancer Cell Metabolism and Phenotypes.

Biomolecules - 9 Feb 2024

Campagna Roberto, Serritelli Emma Nicol, Salvolini Eleonora, Schiavoni Valentina, Cecati Monia, Sartini Davide, Pozzi Valentina, Emanuelli Monica

Abstract excerpt

Paraoxonase-2 (PON2) is a ubiquitously expressed intracellular protein that is localized in the perinuclear region, the endoplasmic reticulum (ER), and mitochondria, and is also associated with the plasma membrane. PON2 functions as an antioxidant enzyme by reducing the levels of reactive oxygen species (ROS) in the mitochondria and ER through different mechanisms, thus having an anti-apoptotic effect and...

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Identifiers

PMID: 38397445
DOI: 10.3390/biom14020208
PMCID: PMC10886763

Genes

PON2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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