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Article

PON2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients.

Atherosclerosis - 15 Feb 2001

Leus F R, Zwart M, Kastelein J J, Voorbij H A

Abstract excerpt

Paraoxonase is an enzyme associated with the high-density lipoprotein (HDL) particle. It catalyses the hydrolysis of organophosphates and protects LDL from oxidative modification in vitro by hydrolyzing lipid peroxides, suggestive of a role for paraoxonase in the development of atherosclerosis. Two frequent mutations at the paraoxonase gene locus (PON1) underlie the leucine (Leu allele) --> methionine (Met...

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Source

Identifiers

PMID: 11257265
DOI: 10.1016/s0021-9150(00)00440-8

Genes

PON2
PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

PON2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients.PMID 11257265Read ↗

DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease.Semantic proximity Read ↗

Polymorphisms associated with apolipoprotein B levels in Greek patients with familial hypercholesterolemia.Semantic proximity Read ↗

The risk of coronary artery disease in population of Taiwan is associated with Cys-Ser 311 polymorphism of human paraoxonase (PON)-2 gene.Semantic proximity Read ↗

Association Between Paraoxonase 2 Ser311Cys Polymorphism and Coronary Heart Disease Risk: A Meta-Analysis.Semantic proximity Read ↗

Paraoxonase gene polymorphisms are associated with carotid arterial wall thickness in subjects with familial hypercholesterolemia.Semantic proximity Read ↗

Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia.Semantic proximity Read ↗

Association of cys 311 ser polymorphism of paraoxonase-2 gene with the risk of coronary artery disease.Semantic proximity Read ↗

Paraoxonase 1 L55M, Q192R and paraoxonase 2 S311C alleles in atherothrombosis.Semantic proximity Read ↗

Paraoxonase (PON1) is associated with familial combined hyperlipidemia.Semantic proximity Read ↗

The Arg allele in position 192 of PON1 is associated with carotid atherosclerosis in subjects with elevated HDLs.Semantic proximity Read ↗

Paraoxonase 2 C311S single nucleotide polymorphism is associated with type C lesions in coronary atherosclerosis.Semantic proximity Read ↗

The role of polymorphisms within paraoxonases (192 Gln/Arg in PON1 and 311Ser/Cys in PON2) in the modulation of cardiovascular risk: a pilot study.Semantic proximity Read ↗

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