Article
A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease.
Neuroscience letters - 1 Jan 2010
Laumet Geoffroy, Petitprez Vincent, Sillaire Adeline, Ayral Anne-Marie, Hansmannel Franck, Chapuis Julien, Hannequin Didier, Pasquier Florence, Scarpini Elio, Galimberti Daniela, Lendon Corinne, Campion Dominique, Amouyel Philippe, Lambert Jean-Charles
Abstract excerpt
Several observations suggest that neurotoxicity in Alzheimer's disease (AD) can be partly attributed to beta-amyloid (Abeta) and senile plaques. Recent work has suggested that the FISH (five SH3 domains) adapter protein and ADAM12 (a disintegrin and metalloprotease) may mediate the neurotoxic effect of Abeta. Both genes are located on chromosome 10, within a region linked to AD (for SH3PXD2A) or nearby (for...
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