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Article

Nanog maintains human chondrocyte phenotype and function in vitro.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Apr 2010

Zheng Hongjun, Gourronc Francoise, Buckwalter Joseph A, Martin James A

Abstract excerpt

Previous work showed that Nanog, a homeobox family transcription factor, maintains embryonic stem cell pluripotency, suggesting that it has a role in stabilizing cell phenotype. Human chondrocytes lose their phenotype and dedifferentiate after relatively few passages in culture, changes that may limit their value in restoring damaged articular cartilage. We hypothesized that Nanog could stabilize the phenotype of...

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Identifiers

PMID: 19834952
DOI: 10.1002/jor.20989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Nanog maintains human chondrocyte phenotype and function in vitro.PMID 19834952Read ↗

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Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells.Semantic proximity Read ↗

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