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Pluripotency Regulators in Human Mesenchymal Stem Cells: Expression of NANOG But Not of OCT-4 and SOX-2

29 Sept 2010

Abstract excerpt

Mesenchymal stem cells (MSCs) are adult multipotent cells able to differentiate toward mature mesodermal lineages. In spite of more than a decade of investigation, little is known about the molecular mechanisms regulating the undifferentiated state and the identity of distinct functional subpopulations in these cells. Transcription factors that regulate the maintenance of the pluripotent state in embryonic stem...

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PMID: 20879854
DOI: 10.1089/scd.2010.0353

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Pluripotency Regulators in Human Mesenchymal Stem Cells: Expression of NANOG But Not of OCT-4 and SOX-2PMID 20879854Read ↗

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OCT4 and PAX6 determine the dual function of SOX2 in human ESCs as a key pluripotent or neural factorSemantic proximity Read ↗

Initiation and maintenance of the pluripotent epiblast in pre-implantation human development is independent of NODAL signalingSemantic proximity Read ↗

Knockdown of NANOG Reduces Cell Proliferation and Induces G0/G1 Cell Cycle Arrest in Human Adipose Stem CellsSemantic proximity Read ↗

Downregulation of NANOG Induces Differentiation of Human Embryonic Stem Cells to Extraembryonic LineagesSemantic proximity Read ↗

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