Article
Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block.
PloS one - 16 Oct 2009
Chatelain Franck C, Gazzarrini Sabrina, Fujiwara Yuichiro, Arrigoni Cristina, Domigan Courtney, Ferrara Giuseppina, Pantoja Carlos, Thiel Gerhard, Moroni Anna, Minor Daniel L
Abstract excerpt
BACKGROUND: Understanding the interactions between ion channels and blockers remains an important goal that has implications for delineating the basic mechanisms of ion channel function and for the discovery and development of ion channel directed drugs. METHODOLOGY/PRINCIPAL FINDINGS: We used genetic selection methods to probe the interaction of two ion channel blockers, barium and amantadine, with the miniature...
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