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Article

Functional screen for subtype specificity of voltage sensor-targeted Kv7 potentiators.

British journal of pharmacology - 1 Sept 2026

Kanyo Richard, Hammond Thomas M, Wang Alice W, Wang Caroline K, Aggarwal Varun, Lamothe Shawn M, Kurata Harley T

Abstract excerpt

BACKGROUND AND PURPOSE: Voltage-gated Kv7 (potassium channel subfamily Q [KCNQ]) potassium channels are powerful modulators of neuronal excitability. ICA-069673 is a N-aryl benzamide drug that targets the voltage-sensing domain (VSD) of Kv7.2 with strong selectivity over Kv7.3 or Kv7.5, but the molecular basis of this selectivity remains poorly understood. Our objective was to identify novel sequence determinants...

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PMID: 42271185
DOI: 10.1111/bph.70531

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