Article
Molecular imaging of activated von Willebrand factor to detect high-risk atherosclerotic phenotype.
JACC. Cardiovascular imaging - 1 Sept 2010
McCarty Owen J T, Conley Robert B, Shentu Weihui, Tormoen Garth W, Zha Daogang, Xie Aris, Qi Yue, Zhao Yan, Carr Chad, Belcik Todd, Keene Douglas R, de Groot Philip G, Lindner Jonathan R
Abstract excerpt
OBJECTIVES: We hypothesized that noninvasive molecular imaging of activated von Willebrand factor (vWF) on the vascular endothelium could be used to detect a high-risk atherosclerotic phenotype. BACKGROUND: Platelet-endothelial interactions have been linked to increased inflammatory activation and prothrombotic state in atherosclerosis. These interactions are mediated, in part, by platelet glycoprotein (GP) Ibα,...
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