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Article

Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease.

Molecular and cellular biology - 15 Dec 2017

Ishimoto Yu, Inagi Reiko, Yoshihara Daisuke, Kugita Masanori, Nagao Shizuko, Shimizu Akira, Takeda Norihiko, Wake Masaki, Honda Kenjiro, Zhou Jing, Nangaku Masaomi

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) constitutes the most inherited kidney disease. Mutations in the PKD1 and PKD2 genes, encoding the polycystin 1 and polycystin 2 Ca2+ ion channels, respectively, result in tubular epithelial cell-derived renal cysts. Recent clinical studies demonstrate oxidative stress to be present early in ADPKD. Mitochondria comprise the primary reactive oxygen species source...

Topics

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Calcineurin
Cysts
Extracellular Signal-Regulated MAP Kinases
Nitric Oxide Synthase
p38 Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polycystic Kidney, Autosomal Dominant

TRPP Cation Channels

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Identifiers

PMID: 28993480
DOI: 10.1128/MCB.00337-17
PMCID: PMC5705822

Genes

PGC
PKD1
PKD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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