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Childhood trauma, family functioning, and the BDNF gene may affect the development of alcohol use disorder.

Drug and alcohol dependence - 1 Jan 2026

Yeh Yi-Wei, Chen Catherine Shin Huey, Kuo Shin-Chang, Chen Chun-Yen, Huang Yu-Chieh, Huang Jyun-Teng, Yang You-Ping, Huang Jhih-Syuan, Ma Kuo-Hsing, Huang San-Yuan

Abstract excerpt

BACKGROUND: Childhood trauma and family dysfunction substantially increase the risk of alcohol use disorder (AUD) among individuals with genetic susceptibility. Brain-Derived Neurotrophic Factor (BDNF) plays a crucial role in neuronal neuroplasticity. METHODS: The cross-sectional case-control study examines the associations between the BDNF gene, childhood trauma, and family functioning in relation to...

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Identifiers

PMID: 41353910
DOI: 10.1016/j.drugalcdep.2025.112987

Genes

BDNF
ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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