Article
Critical role for the immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection.
European journal of immunology - 1 Dec 2009
Tu Liping, Moriya Chikako, Imai Takashi, Ishida Hidekazu, Tetsutani Kohhei, Duan Xuefeng, Murata Shigeo, Tanaka Keiji, Shimokawa Chikako, Hisaeda Hajime, Himeno Kunisuke
Abstract excerpt
Proteasome-mediated proteolysis is responsible for the generation of immunogenic epitopes presented by MHC class I molecules, which activate antigen-specific CD8+ T cells. Immunoproteasomes, defined by the presence of the three catalytic subunits LMP2, MECL-1, and LMP7, have been hypothesized to optimize MHC class I antigen processing. In this study, we demonstrate that the infection of mice with a protozoan...
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