HIV-1 Nef interacts with LMP7 to attenuate immunoproteasome formation and MHC-I antigen presentation

Abstract excerpt

<h4> Abstract </h4> Proteasome is major protein degradation machinery and plays essential roles in diverse biological functions. Upon cytokine inductions, proteasome subunits β1, β2, and β5 are replaced by β1i/LMP2, β2i/MECL-1, and β5i/LMP7, leading to the formation of immunoproteasome. Immunoproteasome-degraded products are loaded onto the major histocompatibility complex class I (MHC-I) to regulate immune resp...

Topics

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• Disease
• HIV/AIDS drug development and treatment
• HIV Research and Treatment
• Models, Biological
• Mutation
• Peptidase Inhibition and Analysis
• Proteasome Endopeptidase Complex
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

19c34afb-18de-533f-80e0-3d1748adddcf

DOI

10.1101/697946