Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T cells lacking immunoproteasome subunits MECL-1 and LMP7 hyperproliferate in response to polyclonal mitogens.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2006

Caudill Christy M, Jayarapu Krupakar, Elenich Laura, Monaco John J, Colbert Robert A, Griffin Thomas A

Abstract excerpt

Immunoproteasomes comprise a specialized subset of proteasomes that is defined by the presence of three catalytic immunosubunits: LMP2, MECL-1 (LMP10), and LMP7. Proteasomes in general serve many cellular functions through protein degradation, whereas the specific function of immunoproteasomes has been thought to be largely, if not exclusively, optimization of MHC class I Ag processing. In this report, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine Endopeptidases
Share to Immunologic Memory

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lymphocyte Culture Test, Mixed

Share to Mitogens

Share to Multienzyme Complexes

Share to Proteasome Endopeptidase Complex

Share to Protein Subunits

Share to Spleen

Source

Identifiers

PMID: 16547243
DOI: 10.4049/jimmunol.176.7.4075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T cells lacking immunoproteasome subunits MECL-1 and LMP7 hyperproliferate in response to polyclonal mitogens.PMID 16547243Read ↗

Critical role for the immunoproteasome subunit LMP7 in the resistance of mice to Toxoplasma gondii infection.Semantic proximity Read ↗

Tumor cell lines expressing the proteasome subunit isoform LMP7E1 exhibit immunoproteasome deficiency.Semantic proximity Read ↗

Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV‐induced meningitisSemantic proximity Read ↗

The Role of Proteasomes in the Thymus.Semantic proximity Read ↗

Proteasome immunosubunits protect against the development of CD8 T cell-mediated autoimmune diseases.Semantic proximity Read ↗

Regulation of Immunoproteasome Subunit Expression In Vivo Following Pathogenic Fungal InfectionSemantic proximity Read ↗

Immune defects in 28-kDa proteasome activator gamma-deficient mice.Semantic proximity Read ↗

Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81.Semantic proximity Read ↗

Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses.Semantic proximity Read ↗

Tissue-Specific Up-Regulation of B7-1 Expression and Function During the Course of Murine Relapsing Experimental Autoimmune EncephalomyelitisSemantic proximity Read ↗

Growth retardation in mice lacking the proteasome activator PA28gamma.Semantic proximity Read ↗

MHC-linked LMP gene products specifically alter peptidase activities of the proteasome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.