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Article

T cells lacking immunoproteasome subunits MECL-1 and LMP7 hyperproliferate in response to polyclonal mitogens.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2006

Caudill Christy M, Jayarapu Krupakar, Elenich Laura, Monaco John J, Colbert Robert A, Griffin Thomas A

Abstract excerpt

Immunoproteasomes comprise a specialized subset of proteasomes that is defined by the presence of three catalytic immunosubunits: LMP2, MECL-1 (LMP10), and LMP7. Proteasomes in general serve many cellular functions through protein degradation, whereas the specific function of immunoproteasomes ha...

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Source

Identifiers

PMID: 16547243
DOI: 10.4049/jimmunol.176.7.4075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16547243-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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